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The KPV peptide is a tripeptide composed of proline, lysine, and valine with anti-inflammatory and antimicrobial properties. Originally derived from the alpha-melanocyte-stimulating hormone (α-MSH), KPV has demonstrated a number of key functions reducing inflammation, enhancing wound healing, and improving skin conditions such as eczema and psoriasis [1]. The ability of the KPV peptide to modulate immune responses makes it extremely valuable not only for dermatological applications but also for managing inflammatory bowel diseases like Crohn’s disease or colitis. Generally, KPV administered topically, orally, or via injection, offering flexibility depending on the targeted use and intended outcome of the study.
Research continues to explore its therapeutic potential for broader inflammation-related disorders and immune regulation [2].
Molecular Formula: C16H3oN4O4
Amino Acid Sequence: Lys-Pro-Val
Molecular Weight: 342.43 g/mol
View the KPV HPLC Certificate here.
Source: PubChem
Buy KPV Peptide Vial here – Available in 2mg peptide vials for research use only.
All peptide vials containing lyophilized peptide require peptide reconstitution using Sterile or Bacteriostatic Water – view the full range of research consumables.
KPV peptide has a unique way of working that helps bring about healing effects thanks to its ability to reduce inflammation and ward off infections. It’s derived from a hormone called alpha-melanocyte-stimulating hormone (α-MSH).
What’s interesting is that KPV connects with specific receptors in our immune cells, namely MC-1R and MC-3R, which are found on cells like macrophages and neutrophils. When KPV binds to these receptors, it actually helps to stop the release of certain substances in the body that can cause inflammation, such as TNF-α, IL-1β, and IL-6. This action ultimately helps to lower inflammation on a molecular level.
Additionally, KPV demonstrates antimicrobial activity by directly disrupting bacterial cell membranes and reducing microbial adhesion to tissues, which helps prevent infections during wound healing [3]. Its ability to modulate inflammation also reduces oxidative stress, promoting cellular repair and maintaining tissue integrity. The peptide further enhances the healing process by promoting epithelial cell migration and regeneration. These mechanisms collectively make KPV effective for managing conditions like inflammatory bowel disease, skin disorders, and other inflammation-driven health issues [2].
Require a fast acting solution to your research? Buy KPV Nasal Spray – available in 15ml or 30ml Peptide Nasal Sprays
Reduces Inflammation
KPV can moderate the immune response by allowing interaction with the melanocortin (MCR) receptors. Found on macrophages and neutrophils, particularly MC-1R and MC-3R constitute these sites When KPV bonds to these receptors, it arrests the production and release of pro-inflammatory cytokines including TNF-α, IL-1β and IL-6. Those cytokines are major agents causing inflammation in body tissues. KPV suppresses their activity prevents Therefore by down-regulating the inflammatory response story at one stroke [1].
KPV also attacks oxidative stress, a common accompaniment of chronic inflammation, and encourages cell repair. Moreover, by adjusting the body’s immune response KPV must ensure that an inflammation-controlled situation will not even set up a backdrop for an infection. The manner in which KPV performs these two roles makes it especially effective for such conditions related to inflammation as skin diseases, inflammatory bowel diseases and a host of other chronic inflammatory states [2].
Promotes Wound Healing and Tissue Repair
KPV promotes wound repair through several mechanisms that enhance tissue healing and regeneration. It reduces inflammation by inhibiting pro-inflammatory cytokines like TNF-α, IL-1β, and IL-6, which can otherwise delay the healing process. By controlling inflammation, KPV creates a more favourable environment for normal tissue repair [3].
Additionally, KPV stimulates epithelial cell migration and proliferation, which are critical steps in closing wounds and regenerating damaged tissue. Its antimicrobial properties also help prevent infections at the wound site, further supporting the healing process.
By reducing oxidative stress and promoting cellular health, KPV ensures that the repair process proceeds efficiently, making it a valuable tool for wound healing, tissue regeneration and scar reduction giving better cosmetic result [3].
Antimicrobial Properties
KPV helps protect against bacterial infections primarily through its antimicrobial properties. It can directly disrupt bacterial cell membranes, impairing their structure and function, which leads to the destruction of the bacteria [4]. Additionally, KPV reduces bacterial adhesion to tissues, making it harder for pathogens to establish infections at wound sites or in inflamed areas including intestinal inflammation.
By modulating the immune response, KPV also prevents excessive inflammation, which can sometimes weaken the body’s natural defenses against infections. This balanced approach allows KPV to support the immune system in fighting off bacteria while promoting healing and reducing the risk of secondary infections. These properties make it particularly useful in managing wounds, skin conditions, and other scenarios where bacterial infections are a concern.
Possible Therapeutic Treatment for Eczema and Psoriasis
Recent clinical trials have demonstrated that KPV may offer potential benefits for individuals living with eczema and psoriasis due to its powerful anti-inflammatory, antimicrobial, and skin-healing properties. By inhibiting key inflammatory pathways and reducing cytokines like TNF-alpha, KPV helps alleviate the chronic inflammation driving these conditions. Its antimicrobial effects combat harmful bacteria, such as Staphylococcus aureus, often linked to eczema flare-ups [5].
Additionally, KPV promotes faster wound healing, normalizes skin cell turnover, and relieves symptoms like redness, itching, and dryness. Unlike traditional treatments such as steroids, KPV targets the root causes without severe side effects, making it a safer, more sustainable option for managing these skin conditions.
Reduces Inflammation of the Intestine
Current research on KPV shows that the peptide offers promise of reducing intestinal inflammation significantly. KPV starts down the pro-inflammatory pathways, such as NF-κB. It helps keep the immune system from over-reacting and hitting everything in sight, which is a symptom commonly associated with several different diseases. Indeed, tests on animal models show that KPV helps to preserve the gut’s epithelial barrier in the face of irritating substances. Against the bacteria and fungi that can spark inflammation, it delivers antimicrobial functions as well. All these effects point to KPV playing a valuable role in treating conditions such as inflammatory bowel disease (IBD): a kind of ailment, that through chronically riddling the gut with inflammation has no discrimination at all. By reducing flare-ups and supporting tissue repair, KPV holds out hope for significantly improving the lives of those suffering from these troublesome problems [6].
Buy KPV Germany from Pharma Lab Global website. A trusted supplier of peptides for laboratory use.
When stacked together, in research BPC-157 and KPV peptide nasal sprays seem to deliver enhanced effects, particularly for inflammatory diseases like psoriasis and eczema. BPC-157 is known for its ability to repair tissues and support gut health, promoting faster healing of injuries to both the skin and internal systems. On the other hand, KPV is known for its strong anti-inflammatory and antimicrobial properties, which help to ease symptoms such as itching, redness, and infection.
The combination of the BPC-157 KPV peptides could offer a synergistic approach to research, reducing inflammation whilst simultaneously repairing tissue and encouraging overall recovery. This synergy presents a promising option for individuals seeking an alternative way to manage chronic inflammatory conditions, potentially with fewer side effects compared to conventional treatments.
Buy KPV & BPC-157 Nasal Spray Combo.
PharmaLabGlobal is one of the best locations to purchase Peptide Combinations for clinical research use.
Can KPV have any adverse effects?
In general, people regard KPV as being safe and suited to their bodies, with hardly any side effects reported. It has a natural peptide formation and has been shown in research to be bioactive orally, subcutaneously, intravenously or topically. However, as with any drug there’s a possibility that it may interact with other medicines. If you are using KPV or any kind of peptide therapy, in those cases it is advisable to seek the advice of a suitably qualified healthcare professional.
Is KPV approved for human consumption?
At the current time of writing, KPV has not been approved by the FDA for human consumption. It is currently categorized as a research peptide, and while it is available for purchase, it is typically labelled for in vitro research purposes only. The FDA has noted a lack of sufficient safety data regarding its efficacy in humans.
[1] Pawar K, Kolli CS, Rangari VK, Babu RJ. Transdermal Iontophoretic Delivery of Lysine-Proline-Valine (KPV) Peptide Across Microporated Human Skin. J Pharm Sci. 2017 Jul;106(7):1814-1820.
[2] Xiao B, Xu Z, Viennois E, Zhang Y, Zhang Z, Zhang M, Han MK, Kang Y, Merlin D. Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis. Mol Ther. 2017 Jul 5;25(7):1628-1640.
[3] Bonfiglio V, Camillieri G, Avitabile T, Leggio GM, Drago F. Effects of the COOH-terminal tripeptide alpha-MSH(11-13) on corneal epithelial wound healing: role of nitric oxide. Exp Eye Res. 2006 Dec;83(6):1366-72.
[4] Duarte-Mata DI, Salinas-Carmona MC. Antimicrobial peptides´ immune modulation role in intracellular bacterial infection. Front Immunol. 2023 Mar 28;14:1119574.
[5] Luger TA, Brzoska T. alpha-MSH related peptides: a new class of anti-inflammatory and immunomodulating drugs. Ann Rheum Dis. 2007 Nov;66 Suppl 3(Suppl 3):iii52-5.
[6] Kannengiesser K, Maaser C, Heidemann J, Luegering A, Ross M, Brzoska T, Bohm M, Luger TA, Domschke W, Kucharzik T. Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. Inflamm Bowel Dis. 2008 Mar;14(3):324-31.
How Does BPC-157 Reduce Inflammation?
This blog highlights BPC-157’s potential to reduce inflammation by modulating pro-inflammatory cytokines, promoting blood vessel formation, and protecting against oxidative stress. The peptide is also noted for its ability to repair NSAID-induced gut damage, enhance immune system regulation, and support tissue regeneration.
The article compares BPC-157 with other peptides like KPV and TB500, emphasizing its broader systemic effects.
What is the Best Peptide Combination?
PharmaLabGlobal explores how combinations of peptides such as GHRP-6 and Sermorelin for growth hormone stimulation, TB500 with BPC-157 for tissue repair or KPV with BPC-157 to reduce inflammation might produce greater effects.
These new combinations take advantage of the pure benefits of individual peptides and improve on combinations in areas like muscle growth, remedies for ailments, and immune modulation.
Understanding the Synergistic Effects of KPV and BPC-157 Peptide Combination
This blog explores whether stacking these peptides from PharmaLabGlobal together not only seems to amplify each other’s benefits, but each sustains the effect of the others as well. Research shows it could be beneficial for such things as better healing in tissues and organs, more blood flow, less inflammation etc. This combination shows promise for treating conditions like the ones mentioned earlier: particular benefits include providing relief from inflammatory bowel diseases, support for joint injuries of all kinds, and potential treatment solutions for central nervous system disorders.
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